Author

Jaijeet Singh

The Francis Crick InstituteORCID 0009-0000-0237-7993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christina E. ToomeyiD· 2 shared Joanne LachicaiD· 2 shared Sonia GandhiiD· 2 shared Aaron Z. WageniD· 1 shared Alexander RöntgeniD· 1 shared Alfonso De SimoneiD· 1 shared Ali E. GhareebiD· 1 shared Amir Rafiq KhaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

Christina E. ToomeyORCID

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Author profile →

3 papers

Recent·Most cited

Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson's disease brain tissue

Alexander Röntgen, Giuliana Fusco, Jonathan C. Breiter, Joseph S. Beckwith, Joanne Lachica, Christina E. Toomey, Jaijeet Singh, Oxana l. Klementieva, Sonia Gandhi, Steven F. Lee, Alfonso De Simone, Zenon Toprakcioglu, Michele Vendruscolo

bioRxiv · Jul 9, 2026 · PreprintBiophysics

Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif

Dieter Waschbüsch, Prosenjit Pal, Raja Sekhar Nirujogi, Melanie Cavin, Jaijeet Singh, Dario R. Alessi, Amir Rafiq Khan

This paper reports the crystal structures of TMEM55B and its complex with a RILPL1 peptide, revealing a conserved TBM motif that mediates adaptor recruitment to lysosomes.

Structure · Nov 27, 2025Peer-reviewedBiochemistry

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen, Núria Setó‐Salvia, Olga Kopach, James R. Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E. Clarke, Jaijeet Singh, Ali E. Ghareeb, James Bayne, Melissa Grant‐Peters, Sonia García-Ruiz, , Mina Ryten

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

Science Advances · Apr 11, 2025Peer-reviewedNeuroscience