Johannes v. Lintig

Adaptive Disruption of Carotenoid Metabolism in Cavefish via Loss of Beta-carotene oxygenase 2a (Bco2a)

This study shows that loss-of-function mutations in Bco2a in cavefish lead to increased carotenoid and vitamin A accumulation, providing a physiological advantage in low-oxygen environments.

Retinoic acid production via the ray-finned fish gene beta-carotene oxygenase 1-like is essential for juvenile development

This study shows that bco1l is essential for VA production in betta fish larvae, leading to developmental defects when knocked out.

The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.

Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

This study shows that loss of rlbp1a in zebrafish causes cone dysfunction, lipid deposits, and photoreceptor degeneration, mimicking human retinal diseases caused by RLBP1 mutations.

Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color.

The paper identifies two SNPs associated with salmon flesh color and suggests bco1l as the likely gene responsible for color variation through functional studies.