Cyrille Alexandre

Xrp1 integrates cellular stress through different control modes in Drosophila

This study identifies three distinct mechanisms by which Xrp1 is induced in response to different stresses in Drosophila, highlighting its role in the Integrated Stress Response.

An in vivo chemical genetic approach for targeted glycoproteome analysis in Drosophila melanogaster

This paper introduces FlyMOE, a chemical-genetic platform for targeted glycoproteome analysis in Drosophila, using mass spectrometry to study glycosylation in vivo.

Membrane lipid composition and endocytosis modulate Wingless release from secreting cells

This study shows that membrane lipid composition and endocytosis regulate Wingless release from secreting cells by modulating its dissociation from Wntless.

The blood-brain barrier regulates brain tumour growth specifically via the SLC36 amino acid transporter Pathetic in Drosophila

This study shows that the SLC36 transporter Pathetic in Drosophila blood-brain barrier glia regulates tumour growth under nutrient restriction by modulating mTor-S6K pathway activity.

Insect wings arose with a genetic circuit that extends the useful range of a BMP morphogen

The paper identifies a genetic circuit in Drosophila that enhances BMP signaling at the distal end of the gradient, enabling insect wing development.

Identification of a specialized lipid barrier for Drosophila metamorphosis

The paper identifies a lipid desiccation barrier in Drosophila pupae and adults, showing its role in preventing dehydration during metamorphosis and its adaptation in different species.

Growth-induced physiological hypoxia correlates with growth deceleration during normal development

The paper shows that growth deceleration during development is linked to hypoxia, with HIF-1 regulating TOR signaling to prevent oxygen demand from exceeding supply.

Signalling-dependent refinement of cell fate choice during tissue remodelling

The paper investigates how signalling networks and tissue flows interact during vein refinement in Drosophila pupal wings, showing that cell fate adjustments, not large-scale flows, drive precise patterning.

The ecdysone receptor promotes or suppresses proliferation according toligand level

The paper shows that ecdysone receptor activity promotes or suppresses proliferation depending on ligand levels, with distinct transcriptional responses to different ecdysone doses.

Frizzled-dependent Planar Cell Polarity without Wnt Ligands

The paper shows that Wnt ligands are not essential for Planar Cell Polarity (PCP) in Drosophila wings, as PCP remains normal in the absence of Wnt signaling.

Lessons in genome engineering: opportunities, tools and pitfalls

The paper describes CRISPR/Cas9-based tools for creating genetic modifications in Drosophila and highlights challenges and solutions in genome engineering.