Decoy Antibodies Block Extracellular HSP70, Prevent Self Signaling and Inhibit Melanoma Cell Survival
Noam Ben-Shalom, Shivang Parikh, Lilach Abramovitz, Ron Yefet, Paulee Manich, Dafna Tussia-Cohen, Ori Moskowitz, Roma Parikh, Stav Melamed, Ksenia Polonsky, Sébastien Apcher, Tzachi Hagai, Merav Cohen, Yochai Wolf, Ronnie Shapira‐Frommer, , Natalia Tarnovitski Freund
This study identifies decoy antibodies targeting extracellular HSP70 on melanoma-derived melanosomes, which inhibit tumor growth and survival in preclinical models and correlate with clinical response to immunotherapy.
Cell Reports · Apr 22, 2026Peer-reviewedImmunology