Olivier Kirsh

The paper shows DNA methylation is largely maintained during UV damage repair through recruitment of DNMT1 and DNMT3A, driven by UHRF1 and repair endonucleases, and linked to histone dynamics and transcriptional response.

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

This study identifies immediate DNA methylation changes in the mouse prenatal cortex after alcohol exposure, linking them to gene expression and neurodevelopmental processes.