Jingwen Hu

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study investigates how IL4I1 affects lymphocyte activity in healthy individuals and MS patients, finding it promotes regulatory T-cells in healthy samples but not in MS patients.

The paper uses spatial transcriptomics to study meningeal inflammation in a mouse model, identifying inflammatory gene signatures in adjacent brain parenchyma and highlighting candidate pathways in grey matter pathology.

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.