Tao Huan

FeatureMSEA enables metabolite set enrichment analysis from ambiguous LC-MS metabolomics features, identifying dysregulated pathways in Huntington's disease.

The paper identifies neuronal lipid droplets as conserved structures that regulate energy homeostasis with sex-biased effects in flies and mice.

This study shows that maternal high-sucrose diet during pregnancy alters fetal brain steroid levels but not maternal or fetal blood steroids.

This study identifies the insulin/insulin-like growth factor signaling pathway as a key determinant of higher fat storage in Drosophila females through increased dietary sugar intake and Dilp3 expression.

This study investigates how early-life gut inflammation affects microbiome, endocrine, and behavioral outcomes, revealing sex-specific impacts on microbiota composition, hormone levels, and behavior.

The paper creates a suspect spectral library for untargeted metabolomics by propagating annotations from public MS/MS spectra to improve interpretation of unannotated spectra.

This paper introduces BAGO, a Bayesian optimization method for optimizing LC gradients in untargeted LC-MS, improving compound annotation and spectral purity.

This study identifies triglyceride as a key neutral lipid regulating spermatogenesis in Drosophila by showing that loss of the triglyceride lipase brummer leads to sperm developmental defects.

This paper introduces a bottom-up MS/MS approach for molecular formula discovery, improving annotation accuracy and identifying novel formulas in metabolomics datasets.

MAFFIN improves metabolomics sample normalization by using maximal density fold change with high-quality features and signal correction, enhancing data separation and metabolic feature detection.

The paper reports the heterologous reconstitution of hybrid NRPS-PKS assembly lines that generate a combinatorial library of cyclic lipodepsipeptide protease inhibitors through non-standard biosynthetic mechanisms.