Sébastien Herbert

The One Click Wonder: a retrained automated segmentation pipeline that enables quantitative and modular analysis of C. elegans embryos

The paper introduces OCW, an automated segmentation pipeline for C. elegans embryos, and BAAM for single-cell quantitation, revealing distinct cell populations with varying transcriptional burst frequencies.

Microgeography of staphyloccoci in human tissue explains antibiotic failure

The paper maps Staphylococcus aureus microgeography in human tissue using AI-guided imaging and finds antibiotic failure is linked to intracellular bacterial persistence and metabolic constraints.

Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression

The paper links apical size and deltaA expression to neural stem cell activation and division modes in zebrafish, showing their independence from Notch signaling.

LocalZProjector and DeProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.

The paper introduces LocalZProjector and DeProj, tools for accurate 2D projection and morphometric analysis of 3D microscopy images, showing they handle complex data and correct projection distortions.

Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

The paper shows neural stem cells use local feedback mechanisms with delays to coordinate their division and maintain homeostasis in the adult brain.