Nitzan Gonen

A conserved regulatory atlas reveals enhancers critical for mouse and human gonadal development

The paper constructs a comparative regulatory atlas of gonad development using mouse and human data, identifies a conserved enhancer critical for gonadal development, and prioritizes non-coding variants in DSD patients.

Male fertility is independent of Enh13 control of Sox9 testicular expression

This study shows that Enh13 is required for initiating male development but not for maintaining Sox9 expression and male fertility in differentiated testes.

The gene regulatory landscape driving mouse gonadal supporting cell differentiation

The paper identifies key transcription factors and regulatory elements involved in mouse gonadal sex determination through integrated transcriptomic and chromatin accessibility analyses.

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

This study identifies time- and sex-specific transposable element expression and epigenetic signatures in mouse fetal gonads, suggesting their role in regulating sex-specific gene expression.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.