Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay.
Yujie Zhang, Lilit Nersisyan, Eliška Fürst, Ioannis Alexopoulos, Carlos Santolaria, Susanne Huch, Claudio Bassot, Elena Garré, Per Sunnerhagen, Ilaria Piazza, Vicent Pelechano
The paper shows that ribosomes modulate transcriptome abundance through frameshifts and out-of-frame mRNA decay in yeast under poor nutritional conditions, with conservation across species.
Molecular Cell · May 1, 2025Peer-reviewedMolecular Biology