Author

Ryann A. Joseph

University of PennsylvaniaORCID 0000-0002-0795-6094Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:multiome· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Michael J. MitchelliD· 4 shared Hannah M. YamagataiD· 3 shared Adele S. RicciardiiD· 2 shared Ajay S. ThatteiD· 2 shared Drew WeissmaniD· 2 shared Hannah C. GeisleriD· 2 shared Kushol GuptaiD· 2 shared Lulu XueiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBioengineering

Michael J. MitchellORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy

Marshall Scott Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna Narateapvathdey Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell

This paper develops a lipid nanoparticle co-delivering mRNA and a small molecule drug to treat oral cancer by enhancing chemotherapy and reshaping the tumor microenvironment.

Advanced Materials · Jul 14, 2026Peer-reviewedBioengineering

High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy

Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat-Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, , Michael J. Mitchell

Advanced Materials · Jan 28, 2026Peer-reviewedBioengineering

Anti-CD38-Targeted Piperazine-Derived Lipid Nanoparticles Overcome Hepatic Clearance for mRNA Delivery to Multiple Myeloma Cells In Vivo

Christian G. Figueroa‐Espada, Hannah C. Geisler, Ryann A. Joseph, Adele S. Ricciardi, Ann E. Metzloff, Joshua O. Acosta-González, Lulu Xue, Hannah M. Yamagata, Ajay S. Thatte, Michael J. Mitchell

This study develops anti-CD38 lipid nanoparticles for targeted mRNA delivery to multiple myeloma cells, improving tumor targeting and reducing hepatic accumulation.

bioRxiv · Nov 12, 2025 · PreprintBioengineering

Elucidating lipid nanoparticle properties and structure through biophysical analyses

Marshall Scott Padilla, Sarah J. Shepherd, Andrew R. Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A. Joseph, Hannah M. Yamagata, Adele S. Ricciardi, Kaitlin Mrksich, David Issadore, Kushol Gupta, Michael J. Mitchell

This study uses biophysical methods to characterize lipid nanoparticle properties and predict their transfection efficiency.

Nature Biotechnology · Oct 23, 2025Peer-reviewedBioengineering