Author

Luke Sebastian

Dana-Farber Cancer InstituteORCID 0000-0002-6863-9420Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:mixed model· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Abhilash JayarajiD· 2 shared Chelsea BraithwaiteiD· 2 shared Haribabu ArthanariiD· 2 shared Hyuk‐Soo SeoiD· 2 shared Abhishek Kumar· 1 shared Aditya KumariD· 1 shared AkshatKumar NigamiD· 1 shared Alán Aspuru‐GuzikiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Abhilash JayarajORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 29, 2026

Optimization of the NFκB-DNA ensemble leads to high affinity binding of partial consensus sites

Tristan R. Gunther, Sophia Hofmeister, Luke Sebastian…·Elizabeth A. Komives

The paper investigates how NFκB (RelA/p50) achieves high-affinity binding to partial consensus DNA sequences through structural rearrangements and dynamic interactions.

DOI 10.64898/2026.10.26.762037

ChIP-seqmixed model

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Molecular BiologybioRxivPreprintApr 10, 2024

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun…·Bruce M. Spiegelman

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

7 citations

mouseproteomics

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BioinformaticsbioRxivPreprintApr 25, 2023

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

Domiziana Cecchini, AkshatKumar Nigam, Ming Tang…·Christoph Gorgulla

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.

24 citations

experimental assaydrug response / drug discovery

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