Laura Breimann

This study shows that spreading α-synuclein alters organelle communication and disrupts neuron-astrocyte mitochondrial quality control.

The paper establishes an ALS hiPSC model showing axonal downregulation of neuromuscular junction proteins and identifies FUS binding to their mRNAs.

This study develops a method to induce meiosis from human pluripotent stem cells, showing key meiotic stages and gene expression similar to in vivo oogonia.

The paper develops a smFISH method with computational staging to study transcription dynamics in C. elegans embryos and finds that the DCC reduces dpy-23 transcription frequency.

The paper introduces tkPAINT, a method combining TIRF microscopy and Tokuyasu cryosectioning to enhance DNA-PAINT for single-protein imaging and molecular counting with 3 nm precision across cells and tissues.

RS-FISH detects FISH spots accurately and efficiently in 2D and 3D images, supporting applications like smFISH and spatial genomics.