Silke J. A. Lochs

This paper introduces Waldo, a genetic barcoding system that links live-cell imaging phenotypes to single-cell sequencing data for the same cells.

The paper identifies genome-lamina reorganization preceding long gene activation in mouse corticogenesis and links it to MeCP2 binding.

MAbID enables simultaneous profiling of multiple chromatin states in single cells, revealing multifactorial chromatin state changes during neural differentiation.

This study identifies H3K27me3's role in regulating genome-nuclear lamina interactions and allelic asymmetry during early mouse embryogenesis through single-cell LAD profiling and chromatin state analysis.