Sandra S. de Vries

MeCP2 binding and genome-lamina reorganization precede long gene activation during mouse corticogenesis

The paper identifies genome-lamina reorganization preceding long gene activation in mouse corticogenesis and links it to MeCP2 binding.

Time-resolved and multifactorial profiling in single cells resolves the order of heterochromatin formation events during X-chromosome inactivation

The paper introduces Dam&ChIC, a method for time-resolved chromatin profiling in single cells, revealing that genome-lamina detachment precedes H3K27me3 accumulation during X-chromosome inactivation.

Genome-wide profiling of DNA repair proteins identifies higher-order coordination in single cells

This study identifies higher-order coordination of DNA repair proteins in single cells by analyzing their genome-wide localization using DamID and ChIC sequencing.

Single-cell profiling of transcriptome and histone modifications with EpiDamID

This paper introduces EpiDamID, a method to profile histone modifications and transcriptomes at single-cell resolution, and demonstrates its application in mouse and zebrafish systems.

Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells

This paper introduces a method to simultaneously measure protein-DNA contacts and transcriptomes in single cells, revealing how chromatin states and genome organization influence gene expression.