Author

Laurence A. Brown

University of OxfordORCID 0000-0001-8116-4100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Approach:statistical model· 1

Frequent Co-Authors

Stuart N. PeirsoniD· 4 shared Alex J. H. FedoreciD· 2 shared Oakley B. MorganiD· 2 shared Roxana FloreaiD· 2 shared Sandrine M. GérantoniD· 2 shared Sara HestehaveiD· 2 shared Andrew P. PattoniD· 1 shared Annia WrightiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Stuart N. PeirsonORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms

Sara Hestehave, Roxana Florea, Samuel Singleton, Alex J. H. Fedorec, Sara Caxaria, Oakley B. Morgan, Katharina Tatjana Kopp, Laurence A. Brown, Tim Heymann, Shafaq Sikandar, Felix Hausch, Stuart N. Peirson, Sandrine M. Géranton

This study shows that inhibiting FKBP51 early in joint pain reduces both sensory and emotional symptoms for up to 6 months, while late inhibition only provides temporary relief.

Proceedings of the National Academy of Sciences · Oct 30, 2025Peer-reviewedNeuroscience

Magnetic Fields Influence Visual Responses in Mice

Ma’ayan Semo, Steven Hughes, Nicola Jane Smyllie, Andrew P. Patton, Carina A. Pothecary, Shu K. E. Tam, Julia Buckland, Laurence A. Brown, Paul Kirkpatrick Reardon, David M. Bannerman, Mark W. Hankins, Michael Harvey Hastings, Stuart N. Peirson

This study shows magnetic fields affect c-Fos expression in mouse retinas and influence exploratory behavior and circadian rhythms, suggesting a retinal response to magnetic fields in mammals.

bioRxiv · May 12, 2025 · PreprintNeuroscience

Predicting hypersensitivity and comorbid depressive-like behavior in late stages of joint disease using early weight bearing deficit

Sara Hestehave, Roxana Florea, Alex J. H. Fedorec, Maria Jevic, Lucile Mercy, Annia Wright, Oakley B. Morgan, Laurence A. Brown, Stuart N. Peirson, Sandrine M. Géranton

The paper shows that early functional measures in joint disease models predict long-term sensory and emotional symptoms, suggesting their use in clinical settings for better pain management and prevention of emotional comorbidities.

bioRxiv · Nov 29, 2023 · PreprintNeuroscience

Aberrant synaptic release underlies sleep/wake transition deficits in a mouse Vamp2 mutant

Gareth T. Banks, Mathilde C. C. Guillaumin, Ines Heise, Petrina Lau, Minghui Yin, Nora Bourbia, Carlos Aguilar, Michael R. Bowl, Chris T. Esapa, Laurence A. Brown, Sibah Hasan, Erica Tagliatti, Elizabeth Nicholson, Rasneer Sonia Bains, Sara E. Wells, , Patrick M. Nolan

This study identifies a Vamp2 mutation in mice that causes sleep-wake transition deficits by reducing synaptic release probability.

bioRxiv · Jan 9, 2020 · PreprintNeuroscience