Author

Wei Cao

Baylor College of MedicineORCID 0000-0002-8952-9159Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Wei Cao1 paper · Jiangnan University

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ethan R. RoyiD· 4 shared Sanming Li· 3 shared Gabriel S. Chiu· 2 shared Adrian BeckmanniD· 1 shared Bess E FrostiD· 1 shared Bradley T. HymaniD· 1 shared Clare PridansiD· 1 shared Constance Lynn AtkinsiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Ethan R. RoyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner

Ethan R. Roy, Qiang Wang, Kexin Huang, Sanming Li, Yuanyuan Fan, Estrella Escobar, Constance Lynn Atkins, Shuning Huang, Juan J. Herrera, Wenbo Li, Clare Pridans, Xiaobo Zhou, Cynthia Ju, Wei Cao

This study shows that non-mutated human tau causes neurodegeneration in a microglia-dependent manner in a mouse model of Alzheimer's disease.

Scientific Reports · Jul 29, 2025Peer-reviewedNeuroscience

Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

Ethan R. Roy, Sanming Li, Sepideh Saroukhani, Yanyu Wang, Wei Cao

This study shows that type I interferon signaling in microglia contributes to neuroinflammation and aging in the mouse brain.

Molecular Neurodegeneration · Jun 17, 2024Peer-reviewedNeuroscience

Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques

Ethan R. Roy, Gabriel S. Chiu, Sanming Li, Nicholas E. Propson, Hui Zheng, Wei Cao

This study identifies type I interferon signaling as a key driver of memory impairment in Alzheimer's disease by promoting neuroinflammation and synaptic loss in a mouse model.

bioRxiv · Nov 1, 2021 · PreprintNeuroscience

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L. DeVos, Bradley T. Hyman, Gabriel S. Chiu, Ethan R. Roy, Wei Cao, Miranda E. Orr, Virginie Buggia-Prévot, William J. Ray, Bess E Frost

This study shows that pathogenic tau accelerates transposable element activation in the aging mouse brain, particularly ERVs, suggesting a link between tauopathy and transposable element-induced neurotoxicity.

Progress in Neurobiology · Oct 18, 2021Peer-reviewedNeuroscience