Pierre-Yves Plaçais

This study shows that reducing Letm1 increases mitochondrial Ca2+ retention, overactivates metabolism, and enhances long-term memory in flies and mice.

This study uses NAD(P)H FLIM to map metabolic profiles in Drosophila mushroom bodies, revealing spatial heterogeneities and learning-induced metabolic changes.

This study shows that neuronal fatty acid oxidation in Drosophila mushroom bodies is essential for memory formation after intensive training.

The paper shows that PKCdelta mediates the spacing effect on memory consolidation by enhancing mitochondrial metabolism in Drosophila mushroom bodies through dopamine signaling.

This study shows that glia transfer alanine to neurons in Drosophila to support memory formation, revealing a metabolic pathway distinct from the astrocyte-neuron lactate shuttle.

This study identifies an astrocyte-to-neuron H2O2 signaling pathway critical for long-term memory formation in Drosophila, with implications for Alzheimer's disease.

The paper identifies TZAP as a developmental regulator of mitochondrial homeostasis critical for activity-dependent synaptic connectivity in Drosophila.

The paper identifies a novel FTSJ1 pathogenic variant and shows its role in neuron morphology and learning performance through RiboMethSeq and transcriptome analysis in human and Drosophila models.

The paper identifies two LH cell-types in Drosophila that are required for aversive memory retrieval and show that memory information is passed from the mushroom body to the lateral horn.