This study conducts an epigenome-wide association study of PTSD in a South African population, identifying epigenetic changes and accelerated DNA methylation age associated with PTSD severity and comorbid metabolic syndrome.

medRxiv · May 7, 2025 · PreprintGenetic & Genomic Medicine

Genetic Determinants Of Major Depressive Disorder (MDD) Among Adult Persons Living With HIV In Uganda.

Olga Tendo Nsangi, Ronald M. Galiwango, Eugene Kinyanda, Martha Sajatovic, Mark Kaddumukasa, Martin N. Kaddumukasa, Elly Katabira, Catherine Nabbumba, Seedat Soraya, Sian M. J. Hemmings, Segun Fatumo, Allan Kalungi

This study identifies three SNPs suggestively associated with MDD in Ugandan HIV-positive adults, highlighting potential genetic links to psychiatric conditions.

medRxiv · Mar 19, 2025 · PreprintGenetic & Genomic Medicine

LincRNAs involved in DCS-induced fear extinction: Shedding light on the transcriptomic dark matter

Stefanie Malan‐Müller, Vladimir B. C. de Souza, Willie M. U. Daniels, Soraya Seedat, Mark D. Robinson, Sian M. J. Hemmings

The paper identifies lincRNAs and their mRNA targets involved in fear extinction induced by D-cycloserine and links them to neurological and psychiatric traits.

bioRxiv · Nov 8, 2019 · PreprintGenomics

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

Caroline M. Nievergelt, Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia‐Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Shareefa Dalvie, Laramie E. Duncan, Mark W. Logue, Allison C. Provost, Andrew D. Ratanatharathorn, Murray B. Stein, Katy Torres, Allison E. Aiello, , Douglas Maurer

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

bioRxiv · Nov 1, 2018 · PreprintGenetics