David C M Liewald

General cognitive function and the brain's structural connectome

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

Deciphering the Influence of Socioeconomic Status on Brain Structure: Insights from Mendelian Randomization

This study uses Mendelian randomization to investigate the causal relationship between socioeconomic status and brain structure, finding that SES is protective against white matter hyperintensities independent of cognitive ability.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Genetic variants for head size share genes and pathways with cancer

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

Integration of DNA methylation datasets for individual prediction

The paper evaluates normalization methods for DNA methylation data to improve BMI prediction across cohorts when projecting new data onto a reference panel.

Refining epigenetic prediction of chronological and biological age

The paper refines epigenetic predictors of chronological and biological age using large-scale EWAS and external validation, improving cAge prediction and outperforming existing bAge predictors.

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

This study identifies genetic and epigenetic factors associated with inflammatory protein levels in older adults using GWAS and EWAS with a Bayesian framework.

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

This study evaluates how different network thresholding methods affect structural brain network properties and their association with age in the UK Biobank.

Genetic analysis identifies molecular systems and biological pathways associated with household income

This study identifies genetic loci associated with household income and links them to biological pathways and cognitive ability, showing genetic differences between income and education.

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

The paper analyzes whole genome sequencing data from an isolated Shetland population, finding increased ultra-rare variants in exonic and regulatory regions compared to mainland Scottish populations.

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

The paper uses pleiotropic meta-analysis to identify genetic loci associated with cognition, education, and schizophrenia, revealing distinct biological mechanisms for concordant and discordant genetic correlations.

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

The influence of X chromosome variants on trait neuroticism.

This study identifies X chromosome variants associated with neuroticism using UK Biobank data, finding 204 significant markers and estimating X-variant heritability at 0.34%.

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

This study identifies genetic and epigenetic factors associated with neurological protein levels in the Lothian Birth Cohort 1936, revealing potential causal links to neurological diseases.

Associations between vascular risk factors and brain MRI indices in UK Biobank

This study examines associations between vascular risk factors and brain MRI indices in UK Biobank, finding that higher vascular risk is linked to poorer brain health across macro- and microstructural measures.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

Genetic contributions to trail making test performance in UK Biobank

This study examines the genetic architecture of trail making test performance and its genetic correlations with cognitive functions in UK Biobank participants.

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

This study finds reduced white matter integrity in individuals with major depressive disorder using UK Biobank imaging data, but no significant subcortical volume differences.