Shaohe Wang

WHaloForce is a chemigenetic tension sensor that images molecular forces in living cells and animals, revealing tissue-specific force patterns and ovulation-related molecular loading.

This paper presents a device for adapting upright light sheet fluorescence microscopy to image samples at air-liquid interface, demonstrating its use on three biological specimens.

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

This paper develops a CRISPR-Cas9 method for efficient gene knockout in mouse salivary gland epithelial explants, demonstrating effective gene perturbation and its impact on branching morphogenesis.

The paper investigates epithelial morphogenesis in mouse embryonic salivary glands, finding that budding is driven by strong cell-matrix adhesion and weak cell-cell adhesion in peripheral epithelial cells.

This study identifies ZCCHC8's role in degrading pervasive transcripts from various genomic regions, suggesting it regulates non-coding RNA beyond previously known substrates.

The paper describes a method for tissue-specific protein degradation in C. elegans using a GFP-targeting nanobody fused to a ubiquitin ligase adaptor, enabling efficient ablation of GFP-tagged proteins in multiple tissues.