Micah J. Niphakis

This study validates the palmitoylation cycle as a therapeutic target in NRAS-mutant cancers by showing that inhibiting ABHD17 reduces tumor growth and synergizes with MEK inhibitors.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

This study identifies ABHD17 isoforms as deacylases of NOD2, showing that inhibiting them enhances NOD2 membrane localization and function in Crohn's disease-associated variants.

The paper uses scRNA-seq and SCOPE-seq to study adult neurogenesis, identifying NOTUM as a key regulator of V-SVZ NSC differentiation and neurogenesis.