Simone Picelli

The paper identifies transcriptional domains in the zebrafish olfactory bulb that correlate with odor preference and shows specific neuronal subtypes are recruited based on odor preference.

This study shows that human Muller glia can proliferate and differentiate into multiple retinal cell types when exposed to FGF-2 and GSK-3 inhibition.

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

The paper improves the FLASH-seq protocol for long-read scRNA-seq on ONT, develops barcoding strategies, and presents a bioinformatics pipeline, while highlighting technical challenges.

SEQURNA improves gene detection in FLASH-seq compared to commercial inhibitors and eliminates the need for DTT, enhancing data quality and reducing costs.

This study uses explanted SEEG electrodes to integrate RNA sequencing, DNA methylation, and genomic data with electrophysiological recordings, revealing distinct molecular landscapes in epilepsies and identifying potential seizure zones.

The paper introduces FLASH-Seq, a new single-cell RNA-seq method that improves sensitivity and reduces processing time compared to existing protocols.

This paper develops a multimodal approach to study human retinal organoid development, integrating spatial, transcriptomic, and chromatin accessibility data to create a virtual atlas of retinal development.

This study compares cell-type development and transcriptomes in human retinal organoids and adult retinas, finding convergence in transcriptomes and cell-type-specific disease gene expression.

The paper introduces STRT-seq-2i, a high-throughput single-cell RNA-seq platform, and demonstrates its application on fresh mouse and frozen human cortical samples.