Kasit Chatsirisupachai

Molecular co-accessibility identifies coordinated regulation between distant cis-regulatory elements

The paper quantifies co-accessibility between cis-regulatory elements in Drosophila using single-molecule footprinting and long-read sequencing, revealing coordinated regulation across genomic distances.

Cumulative TF binding and H3K27 Acetylation drive enhancer activation frequency

The paper quantifies enhancer activation frequency in response to TF perturbations and identifies H3K27Ac as a chromatin mark required for enhancer activation.

Mammalian promoters are characterised by low occupancy and high turnover of RNA polymerase II

The paper measures RNA Polymerase II occupancy at promoters in mouse and Drosophila, finding lower occupancy and higher turnover in mammals.

Human Ageing Genomic Resources: updates on key databases in ageing research

The paper updates six databases in the Human Ageing Genomic Resources (HAGR) focusing on genes, drugs, and genetic variants related to ageing and longevity.

Pan-cancer transcriptomic analysis reveals a tissue-specific loss of identity

This study identifies a loss of cell identity in ageing and cancer using transcriptomic data, showing distinct patterns in gene expression associated with patient survival.

GeneFriends 2021: Updated co-expression databases and tools for human and mouse genes and transcripts

GeneFriends 2021 updates co-expression networks for human and mouse genes using RNA-seq data from 46,475 and 34,322 samples, respectively.

A Multidimensional Systems Biology Analysis of Cellular Senescence in Ageing and Disease

The paper curates a database of senescence-associated genes and performs systems biology analyses to identify novel regulators and pathways of cellular senescence.