Author

Ichiro Manabe

Chiba UniversityORCID 0000-0001-9481-6673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Takahiro KuchimaruiD· 2 shared Takayuki IsagawaiD· 2 shared Akiko NagamachiiD· 1 shared Akinori KanaiiD· 1 shared Ariunbold Chuluun-ErdeneiD· 1 shared Atsumasa KurozumiiD· 1 shared Christian StockmanniD· 1 shared Daigo SawakiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

Takahiro KuchimaruORCID

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3 papers

Recent·Most cited

Cell-autonomous thermogenesis of macrophage alters its antibacterial function

Hiroki Sugimoto, Takayuki Isagawa, Kazuhiko Miyanaga, Kotaro Kiga, Yuki Sugiura, M. Yamamoto, Ichiro Manabe, Takahiro Kuchimaru, Longzhu Cui, Norihiko Takeda

This study shows that macrophages generate heat through a cell-autonomous mechanism, which reduces their antibacterial function in cold environments.

bioRxiv · Feb 1, 2026 · PreprintPhysiology

The REFLEX system enables in vivo identification of perivascular angiogenic macrophages in the heart

Tatsuyuki Sato, Takayuki Isagawa, Toshinaru Kawakami, Sosuke Hosokawa, Masamichi Ito, Daigo Sawaki, Shigeru Sato, Yu Nakagama, Kazutoshi Ono, Ariunbold Chuluun-Erdene, Thuc Toan Pham, Ryohei Tanaka, Atsumasa Kurozumi, Hiroaki Semba, Masaki Wake, , Norihiko Takeda

The paper develops REFLEX and HUNTERuni-seq to identify perivascular angiogenic macrophages (PVAMs) that deliver VEGF-A to endothelial cells, showing physical contact is critical for effective signaling.

bioRxiv · Jan 30, 2026 · PreprintCell Biology

JMJD3 mediated senescence is required to overcome stress induced hematopoietic defects.

Yuichiro Nakata, Takeshi Ueda, Yasuyuki Sera, Miho Koizumi, Katsutoshi Imamura, Akinori Kanai, Kenichiro Ikeda, Norimasa Yamasaki, Akiko Nagamachi, Kohei Kobatake, Masataka Taguchi, Yusuke Sotomaru, Tatsuo Ichinohe, Zen-ichiro Honda, Takuro Nakamura, , Hiroaki Honda

This study shows JMJD3 promotes senescence in HSPCs to overcome stress-induced hematopoietic defects, with implications for aging and cancer therapies.

EMBO Reports · Jun 25, 2025Peer-reviewedCell Biology