Murray B. Stein

The paper investigates gene-environment interactions between polysubstance dependence and suicidal behaviors using two cohorts, finding significant associations and gene clusters linked to these interactions.

This study identifies genetic variants associated with self-reported childhood maltreatment and finds significant genetic correlations with depressive symptoms.

The paper performs a meta-analysis of DNA methylation data from military cohorts to identify CpG sites and regions associated with PTSD development.

This paper conducts GWAS on anxiety traits in the Million Veteran Program, identifying significant genetic loci and demonstrating genetic overlap with depression.

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.

The paper identifies and validates modifiable factors for depression prevention using UK Biobank data and Mendelian randomization.

This study identifies hippocampal subfield volume differences in PTSD and depression across 31 cohorts, finding depression has a stronger effect than PTSD, especially in CA1, with comorbid cases showing more pronounced changes.

This study identifies reduced fractional anisotropy in the tapetum region of the corpus callosum in PTSD patients using a large multi-cohort analysis of diffusion MRI data.

This study identifies genetic loci associated with psychological resilience in US Army soldiers using GWAS, finding significant associations with neuroticism and specific genes involved in neuronal survival.

This study examines how polygenic risk and protective factors like unit cohesion and trait resilience affect the risk of depression in US Army soldiers after combat deployment.

This study uses metabolome-wide Mendelian randomization to identify causal relationships between blood metabolites and trauma response traits in the UK Biobank.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

This study uses Mendelian randomization to test causal relationships between physical activity and depression, finding protective effects of objective activity measures but not self-reported ones.

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

This study uses genetic data to show that educational attainment causally reduces PTSD risk, with economic status mediating this relationship.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.