Leïla Boubakar

SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo.

This study shows that SYNGAP1 deficiency causes accelerated synaptic development and disrupted neoteny in human cortical neurons transplanted into mice, linking it to ID/ASD.

Species-specific mitochondria dynamics and metabolism regulate the timing of neuronal development

This study shows that slower mitochondrial development and lower metabolic activity in human cortical neurons compared to mice delay neuronal maturation, and stimulating mitochondria accelerates this process.

Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

Spatial and temporal profiling of receptor membrane insertion controls commissural axon responses to midline repellents

The paper investigates how commissural axons develop sensitivity to midline repellents through receptor dynamics during navigation, revealing spatial and temporal receptor profiles that enable discrimination of repulsive signals.