Xiao Qin

Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT)

The paper develops SPOT, a tool for analyzing 3D morpho-dynamics from 2D live-cell imaging, and applies it to organoids to identify phenotype-genotype-function relationships.

Postnatal Reprogramming Shapes Human Intestinal Epithelial Immune Competency

The paper defines the developmental circuits and mechanisms underlying postnatal intestinal epithelial immune competency using single-cell multi-omics and spatial transcriptomics.

SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.

Oncogenic PIK3CA corrupts growth factor signaling specificity

The paper uses single-cell analyses to show that oncogenic PIK3CAH1047R reduces IGF1 signaling specificity and enhances EGF responses, leading to increased phenotypic heterogeneity.