Jenni Durieux

This study shows that macroautophagy-induced lysosomal damage limits quiescent cell re-entry, and reducing this damage can enhance cell cycle re-entry in C. elegans and mammalian cells.

The paper shows that germline mitochondria mediate neuron-to-peripheral UPRMT signaling in C. elegans by responding to mitokines like WNT and serotonin and regulating lipid metabolic pathways.

This study shows glial cells control autophagy and metabolism in C. elegans through non-autonomous activation of HLH-30 in the intestine.

This study shows glial cells in C. elegans sense mitochondrial stress and signal to neurons to improve protein homeostasis and longevity.

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.