Arushi Sahay

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Cell non-autonomous control of autophagy and metabolism by glial cells

This study shows glial cells control autophagy and metabolism in C. elegans through non-autonomous activation of HLH-30 in the intestine.

A mechanical pacemaker sets rhythmic nephron formation in the kidney

This study identifies a mechanical pacemaker in the kidney stroma that synchronizes nephron formation with ureteric bud branching.