Author

Ryo Higuchi-Sanabria

University of Southern California;

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Amin HaghaniiD· 1 shared Amy ChristenseniD· 1 shared Andrew Dillin· 1 shared Annie Hiniker· 1 shared Boyang LiiD· 1 shared Caleb Finch· 1 shared Changhan LeeiD· 1 shared Christian J. PikeiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperEvolutionary Biology

Amin HaghaniORCID

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2 papers

Recent·Most cited

ApoE isoforms establish distinct antioxidant trajectories across the aging brain

Sarah J Shemtov, Mafalda Cacciottolo, Amy Christensen, Boyang Li, Amin Haghani, Michelle C. Rice, Herbert Anson, Claire S. Chung, Whitaker Cohn, Hongqiao Zhang, Wendy J. Mack, Annie Hiniker, Changhan Lee, Todd E. Morgan, Elizabeth Head, , Max A. Thorwald

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

bioRxiv · Nov 9, 2026 · PreprintEvolutionary Biology

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

Joseph R. Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, Melissa Sanchez, Jenni Durieux, Sarah U. Tronnes, Joseph W. Paul, Daniel J. Esping, Samira Monshietehadi, Melissa G. Metcalf, Andrew Dillin

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.

bioRxiv · Nov 15, 2018 · PreprintCell Biology