Author

Shivansh Mahajan

California Institute of TechnologyORCID 0000-0002-3041-7988Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Douglas C. ReesiD· 2 shared William ClemonsiD· 2 shared Adrian ColazoiD· 1 shared Alonso TapiaiD· 1 shared Ashley E. PalliD· 1 shared Benjamin K. YangiD· 1 shared Dongqiang Yuan· 1 shared Edmund D. KapelczakiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Douglas C. ReesORCID

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3 papers

Recent·Most cited

Structural basis of metalloid transport by the arsenite efflux pump ArsB

Shivansh Mahajan, Kemal Demirer, William Clemons, Douglas C. Rees

The paper reports cryo-EM structures of ArsB, revealing its mechanism of metalloid transport and H+/metalloid antiport.

Nature Communications · May 18, 2026Peer-reviewedBiochemistry

Single-Cell Metabolic Imaging Reveals Glycogen Driven-Adaptations in Endothelial Cells

Rahuljeet Singh Chadha, Benjamin K. Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb Kaur Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen Chen, Lu Wei

This study uses SRS microscopy to show that endothelial cells store glycogen under diabetes-like stress, which helps them survive glucose starvation and may offer new therapeutic targets for diabetes-related endothelial dysfunction.

Advanced Science · Nov 26, 2025Peer-reviewedCell Biology

Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA

Shivansh Mahajan, Ashley E. Pall, Yancheng E. Li, Timothy L. Stemmler, Douglas C. Rees, William Clemons

This study reports cryo-EM structures of ArsA, an ATPase involved in arsenite efflux, showing conformational changes driven by nucleotides and AsIII binding.

Proceedings of the National Academy of Sciences · Aug 29, 2025Peer-reviewedBiochemistry