Daniel Lüdke

AI-guided discovery of atypical protein assemblies

The paper introduces SNI, a framework to identify atypical protein assemblies, and applies it to NLRs, finding an undecameric assembly in NRC7 orthologs.

The Pik NLR pair accumulates at the plasma membrane as a hetero-oligomeric sensor-helper immune protein complex prior to activation

The paper shows that the rice NLR pair Pik-1 and Pik-2 forms a hetero-oligomeric complex at the plasma membrane in the resting state before effector activation.

The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in prf mutants of Nicotiana benthamiana

The study shows that autoactive mutants of tomato NRC proteins still induce cell death in prf mutants and in lettuce, indicating a unidirectional dependency in the NRC immune network.

Two genetically linked Arabidopsis TIR-type NLRs are required for immunity and interact with NLRs encoded in a segmentally duplicated genomic region

This study identifies two genetically linked Arabidopsis TIR-type NLRs, TN13 and TNT1, which are required for immunity and interact with other NLRs in a segmentally duplicated genomic region.