Brandon D. Le

Massively parallel assessment of gene regulatory activity at human cortical structure associated variants

The paper assesses regulatory activity of cortical structure-associated variants using MPRA in human neural progenitor cells, identifying 918 variants with regulatory potential and showing condition-dependent effects.

Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium

The paper exposes human neural progenitors to valproic acid and lithium, identifying gene by treatment interactions linked to psychiatric disorder risk and folate metabolism.

Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes

This paper introduces a method to classify gene-by-treatment interactions using Bayesian model selection and applies it to molecular count phenotypes with a software package.

Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis

The paper identifies cell-type-specific genetic regulation of RNA-editing and alternative polyadenylation in human neural progenitors and neurons, linking these to brain-related traits.

WNT activity reveals context-specific genetic effects on gene regulation in neural progenitors

The paper identifies context-specific genetic effects on gene regulation in neural progenitors by stimulating the Wnt pathway and analyzing chromatin accessibility and gene expression.

Cellular genome wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation

The paper identifies a genetic locus on chr3p21.1 associated with lithium-induced neural progenitor proliferation and links it to bipolar disorder risk through the gene GNL3.