Ajay Larkin

Defining the Candidozyma auris pan-genome and essentiality

This study defines the pan-genome of Candidozyma auris and identifies essential genes, revealing organism-specific biology and potential antifungal targets.

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

Epigenetic memory is governed by an effector recruitment specificity toggle in Heterochromatin Protein 1

This study shows that minor amino acid changes in Swi6 can lead to significant changes in epigenetic inheritance by altering effector recruitment specificity.

Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance

This study shows that HP1 proteins are essential for maintaining heterochromatin but not for its establishment, as their function can be bypassed when specific histone modifiers are deleted.

Mapping the dynamics of epigenetic adaptation during heterochromatin misregulation

This study investigates epigenetic adaptation in fission yeast by inducing H3K9me redistribution, revealing slow kinetics and memory-like behavior in chromatin and transcriptional states during stress adaptation.