Yanhui Xu

Kinetic control of mammalian transcription elongation

This study develops a single-molecule platform to analyze mammalian transcription elongation dynamics and identifies kinetic regulation by elongation factors.

Small non-coding RNAs encapsulating mammalian cells fuel innate immunity

The paper identifies and characterizes surface non-coding RNAs, particularly Y RNAs, on human monocytes and B cells, revealing their role in innate immune activation by regulating IL-6 expression.

Stabilization of Integrator/INTAC by the small but versatile DSS1 protein

This study identifies DSS1 as an essential subunit of the INTAC complex, showing its role in stabilizing INTAC and its impact on transcriptional regulation.

Structure of nucleosome-bound human PBAF complex

The paper determines the structure of the human PBAF complex bound to an acetylated nucleosome, revealing its modular organization and binding domains.

RPAP2 regulates a transcription initiation checkpoint by prohibiting assembly of preinitiation complex

The paper identifies RPAP2 as a gatekeeper that prevents preinitiation complex assembly by blocking Pol II-TFIIF interaction, thereby regulating transcription initiation.

U1 snRNP regulates chromatin retention of noncoding RNAs

The paper identifies a U1 snRNP recognition motif that regulates chromatin retention of noncoding RNAs through experimental and computational methods.