Bas van Steensel

The paper investigates how gene activation affects nuclear lamina interactions and shows that transcription can locally rewire these interactions without broadly altering chromosomal regions.

The paper identifies over 30,000 SNPs affecting regulatory element activity using SuRE reporter technology, linking them to gene regulation and potential human traits.

The paper shows that LADs create a repressive chromatin environment that affects promoter activity and transcription elongation, with variability in promoter sensitivity to LAD repression.

The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.

The paper introduces TIDER, a method to quantify template-directed CRISPR/Cas9 editing efficiency using an adapted TIDE approach.

This study shows that ACF1-containing chromatin remodeling complexes repress gene expression by maintaining a repressive chromatin state in Drosophila.

The paper quantifies DSB repair kinetics and fidelity in human cells, finding slow repair (~6h) and high error rate (>70%).