The paper develops a synthetic immunological niche to monitor islet transplant rejection by capturing immune signatures, identifying distinct rejection patterns and biomarkers.

Advanced Science · Oct 8, 2026Peer-reviewedBioengineering

Synthetic Immunological Niche Reveals Early Immune Dysregulationand Stratifies Therapeutic Response in Type 1 Diabetes

Jyotirmoy Roy, Yifei Jiang, Runbo Mao, Jessica L. King, Amod Talekar, Lillian Page Holman, Haoxuan Zeng, Xin Luo, Peter Sajjakulnukit, Bae-Jin Ha, Kai Liu, Elizabeth J. Bealer, Laila M. Rad, Shahzad Sohail, Antonio Louis A. Holmes, , Lonnie D. Shea

The paper develops a synthetic immunological niche to identify early immune dysregulation and stratify therapeutic response in Type 1 Diabetes.

bioRxiv · Mar 10, 2026 · PreprintBioengineering

Microtubule Stabilization and Biomaterial Guidance Synergize to Enhance CST Regeneration and Motor Recovery After Chronic SCI.

Usha Nekanti, Pooja S. Sakthivel, Rebecca A. Nishi, Andrea Anzalone, Courtney M. Dumont, Jeong Bin Lee, Skylar McDonald, Hao Song, Andre Obenaus, Paul David Gershon, Frank Bradke, Lonnie D. Shea, Brian J Cummings, Aileen J. Anderson

This study combines biomaterial scaffolds and microtubule stabilizers to improve axon regeneration and motor recovery in chronic spinal cord injury.

bioRxiv · Feb 8, 2026 · PreprintNeuroscience

Limitations in PPAR-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells

Anne C. Lietzke, Emily M. Walker, Elizabeth J. Bealer, Kelly M. Crumley, Jessica King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle A. Henry-Kanarek, Rebecca K. Davidson, Jin Li, Emma C. Reck, Yifei Wu, Manikanta Arnipalli, , Scott A. Soleimanpour

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

bioRxiv · Jul 26, 2024 · PreprintDevelopmental Biology

Plasticity of fibroblast transcriptional response to physical and biochemical cues revealed by dynamic network analysis

Pilhwa Lee, Joseph T. Decker, Lonnie D. Shea, Daniel Andrew Beard

The paper uses dynamic network analysis to study how human fibroblasts respond to physical and biochemical cues, identifying key transcription factors involved in mechanotransduction pathways.

bioRxiv · Dec 13, 2020 · PreprintSystems Biology

Lentiviral interleukin-10 gene therapy preserves fine motor circuitry and function after a cervical spinal cord injury in male and female mice

Jessica Y. Chen, Emily J. Fu, Paras R. Patel, Alexander Hostetler, Hasan A. Sawan, Kayla A. Moss, Sarah E. Hocevar, Aileen J. Anderson, Cynthia A. Chestek, Lonnie D. Shea

This study shows that interleukin-10 gene therapy reduces lower motor neuron loss and muscle denervation after spinal cord injury, improving motor function in mice.

Neurotherapeutics · Oct 13, 2020Peer-reviewedNeuroscience

Ligands, receptors and transcription factors that mediate inter-cellular and intra-cellular communication during ovarian follicle development

Beatriz Peñalver Bernabé, Teresa K. Woodruff, Linda J. Broadbelt, Lonnie D. Shea

The paper identifies signaling interactions and transcription factors involved in ovarian follicle development using protein interaction networks and public microarray data.

Reproductive Sciences · Jan 14, 2020Peer-reviewedSystems Biology