Tony Kelly

This study evaluates photopharmacology agents in human and mouse brain tissue to control epilepsy, finding that caged propofol suppresses epileptiform activity across species.

The paper shows that dendrites have nanoscale constrictions that create electrical compartments, altering synaptic integration in neurons.

This study shows that early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A-DEE, suggesting it as a therapeutic target.

The paper reports that common AAV transduction procedures can induce artefactual Ca2+ micro-waves in the hippocampus and provides an alternative method to avoid this issue.

The paper identifies a Na+ channel-dependent mechanism in hippocampal dendrites that contributes to spatial memory deficits in epilepsy and shows that targeting Nav1.3 channels can reverse these deficits.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

The paper quantifies how feedback inhibition in the mouse dentate gyrus contributes to frequency-dependent pattern separation of temporally structured inputs.