Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic I. Javonillo, Gema M. Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert A. Edwards, Dequina Nicholas, Gabriela Pacheco Sanchez, Ralph Steven Baric, Kim N. Green, Thomas E. Lane
This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.
bioRxiv · Dec 22, 2025 · PreprintPathology