Athina Georgiadou

Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium

The paper identifies histone lactylation as a new epigenetic mark in malaria parasites, showing its metabolic sensitivity and differential abundance between species.

Anemia and tissue hypoxia are major determinants of malarial hypelactatemia

This study investigates the role of anemia and tissue hypoxia in hyperlactatemia during severe malaria using a murine model and human samples.

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

This study compares transcriptomic profiles between human malaria patients and mouse models to identify which models best reflect human disease features.

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

This study uses dual transcriptome analysis to identify host and parasite gene expression associated with severe malaria in Gambian children, showing parasite load explains most human gene expression differences but only a third of parasite gene differences.

Estimating parasite load dynamics to reveal novel resistance mechanisms to human malaria

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.