Umberto D’Alessandro

The paper identifies genomic signatures of selection in Anopheles funestus across African populations, revealing shared and population-specific adaptive variation linked to insecticide resistance and neuromodulatory pathways.

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

The paper analyzes old Plasmodium falciparum genomes to study malaria parasite adaptation over 50 years, finding strong positive selection at surface protein loci and changes in allele frequencies.

The paper genotypes PIEZO1 STR alleles in malaria cases and controls, finding a modest protective effect of E756del against malaria.

The paper identifies regional subpopulations and gene flow patterns of Plasmodium falciparum in Africa using genome-wide microsatellite loci from 992 isolates.

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

This paper evaluates the cost-effectiveness of precision-guided sterile insect technique (pgSIT) for malaria control in The Gambia, finding it to be a cost-effective and economically beneficial approach.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

The paper uses whole genome sequencing to trace the origin of SARS-CoV-2 strains in The Gambia, identifying European and Asian sources.

This study examines biting and resting preferences of malaria vectors in The Gambia, finding that An. arabiensis prefers outdoor resting while An. coluzzii prefers indoor resting, with associated insecticide resistance mutations.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

The paper estimates parasite load dynamics in malaria to identify host resistance mechanisms, finding novel roles for proteases and detrimental effects of interferon response.