Manuel Mameli

Deletion of TNFR1 in astrocytes restores memory in aged Alzheimer's disease mice

Deleting TNFR1 in astrocytes improves memory in aged Alzheimer's mice by rebalancing hippocampal circuitry excitability through synaptic pathway changes.

Aversion encoding and behavioral state modulation of lateral habenula neurons

The paper identifies electrophysiological diversity in lateral habenula neurons in mice and links firing patterns to aversive stimuli and behavioral states.

Autophagy in parvalbumin interneurons is required for inhibitory transmission and memory via regulation of synaptic proteostasis

This study shows that autophagy in parvalbumin interneurons is essential for synaptic proteostasis, inhibitory transmission, and memory, but not for Purkinje cells.

Synaptic inhibition in the lateral habenula shapes reward anticipation

This study shows that synaptic inhibition in the lateral habenula of mice is crucial for reward anticipation, as enhancing GABAergic transmission increases anticipatory licking behavior.

Heterogeneous habenular neuronal ensembles during selection of defensive behaviors

The paper identifies heterogeneous habenular neuronal clusters in mice that predict or reflect the selection of distinct defensive behaviors in response to visual threats.

Cerebellar dopamine D2 receptors regulate preference for social novelty

This study shows that cerebellar dopamine D2 receptors in Purkinje cells regulate social novelty preference in mice without affecting motor functions.

The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity

This study shows that CYFIP1 haploinsufficiency in mice causes reduced brain functional connectivity and white matter defects, linking it to neuropsychiatric disorders like Autism and Schizophrenia.