Xinghong Dai

Mutational fitness landscapes of diverse human influenza H1N1 neuraminidases

This study quantifies the replication fitness effects of mutations in diverse H1N1 influenza neuraminidases, revealing strain-dependent effects and epistasis patterns.

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation

This study determines the structural basis of SAMD9 autoinhibition and explains how pathogenic mutations disrupt this mechanism to cause disease.

High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display

This study introduces oPool+ display, a high-throughput platform for synthesizing and characterizing natively paired antibodies, demonstrating its application in analyzing influenza HA antibodies.

Genome organization in double-stranded DNA viruses observed by cryoET

This study uses cryoET to observe the 3D organization of dsDNA in viral particles, revealing a conserved 'rod-and-coil' structure and proposing a packaging mechanism.

Different capsid-binding patterns of the β-herpesvirus-specific tegument protein pp150 (pM32/pUL32) in murine and human cytomegaloviruses

This study compares the capsid-binding patterns of pp150 in human and murine cytomegaloviruses using cryoEM, revealing structural differences and functional implications for using MCMV as a model for HCMV.