Georgios Baskozos

Precision cell-state silencing of injured afferents alleviates spontaneous neuropathic pain

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

Extended maturation of the HD10.6 immortalised human dorsal root ganglion cell line enables modelling of nociceptive responses and neural injury

The paper characterizes the maturation of HD10.6 human dorsal root ganglion cells over 28 days, showing transcriptional and functional changes relevant to nociception and axon injury.

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

Predicting pain genes: multi-modal data integration using probabilistic classifiers and interaction networks

This paper identifies potential pain-related genes using machine learning and interaction networks, finding JAK2/STAT3, ErbB, and Rap1 pathways as promising targets.

Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury

The paper analyzes bulk RNA-seq data from murine dorsal root ganglia neurons after nerve injury to identify sex-specific transcriptional changes across neuronal subtypes.

DIRC3-IGFBP5 is a shared genetic risk locus and therapeutic target for carpal tunnel syndrome and trigger finger

The paper identifies DIRC3-IGFBP5 as a shared genetic risk locus for trigger finger and carpal tunnel syndrome, linking IGF-1 signaling to both diseases.

Molecular and cellular correlates of human nerve regeneration: ADCYAP1 encoding PACAP enhances sensory neuron outgrowth

The paper identifies ADCYAP1 (PACAP) as a key molecule enhancing sensory neuron outgrowth in human nerve regeneration using carpal tunnel syndrome as a model.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice

The paper identifies 267 NaV1.7-associated proteins in mice using epitope-tagged gene targeting and mass spectrometry, including novel interactors validated by co-immunoprecipitation and functional assays.