Author

Fernanda Teixeira Subtil

The Francis Crick InstituteORCID 0000-0002-8607-6887Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Aurora Irene IdilliiD· 2 shared James I. MacRaeiD· 2 shared Sandra Segura‐BayonaiD· 2 shared Simon J. BoultoniD· 2 shared Adrian HaydayiD· 1 shared Andrew J. Powell· 1 shared Annabel BorgiD· 1 shared Antonia LandwehriD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Aurora Irene IdilliORCID

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3 papers

Recent·Most cited

MEN1 deficiency establishes a selenite-dependent binary switch in ferroptosis

Ronnie Ren Jie Low, Nishita Parnandi, Aurora Irene Idilli, Ersa Gjelaj, Fernanda Teixeira Subtil, Sandra Segura‐Bayona, James I. MacRae, Simon J. Boulton

The paper shows MEN1 deficiency reduces ferroptosis by altering ACSL1 and GPX4 levels, with selenite affecting resistance.

bioRxiv · Aug 12, 2026 · PreprintCell Biology

Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells

Federica Raguseo, Elliot Fellows, Cesira de Chiara, Benjamin J. Mortishire-Smith, Sandra Segura‐Bayona, Emma E. Cawood, Ming Jiang, Fernanda Teixeira Subtil, Aurora Irene Idilli, William J. McCarthy, Michael Howell, Katrin Rittinger, James I. MacRae, Mark J. Skehel, Andrew J. Powell, , Simon J. Boulton

The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.

bioRxiv · Jun 11, 2026 · PreprintCell Biology

The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice

Le D. He, Harriet Feldman, Timothy Nguyen, Marion Bosc, Vasishta Polisetty, Orla Kriel, Antonia Landwehr, Annabel Borg, Fernanda Teixeira Subtil, Mohammadparsa Khakpour, Jitong Zhou, Svend Kjær, James Hunter MacCabe, Thomas Arthur Pollak, Marie‐Ève Tremblay, , Katharina Schmack

This study shows clozapine reduces anti-NMDAR autoantibodies and psychosis-like behaviors in mice by suppressing autoimmunity.

bioRxiv · Mar 31, 2026 · PreprintNeuroscience