Xiaoqian J. Chai

Development of functional topography of the default mode subnetworks revealed by precision mapping

This study maps individualized default mode network subnetworks across development, finding increased functional segregation and spatial distinctiveness with age.

Thalamocortical orchestration of human theory of mind

This paper investigates thalamocortical dynamics during theory of mind tasks using fMRI and sEEG, finding that the thalamus coordinates default network activity through phase-amplitude coupling without local activation.

Fiber-tract development contributes to functional specialization in the human hippocampus

The paper examines how fiber-tract development in the human hippocampus correlates with functional specialization across childhood, finding that cross-sectional area of specific tracts predicts functional specialization.

Characterising the association between posterior parietal metabolite levels and cortical macrostructure in a cohort spanning childhood to adulthood.

This study examines the relationship between posterior parietal metabolite levels and cortical macrostructural metrics in a developmental cohort, finding significant associations between metabolites and structural features like thickness and gyrification.

Enhanced efficiency in the bilingual brain through the inter-hemispheric cortico-cerebellar pathway in early second language acquisition

This study shows that early second language acquisition enhances global brain network efficiency through the inter-hemispheric cortico-cerebellar pathway.

Contracted Functional Connectivity Profiles in Autism

This study finds reduced cortex-wide connectivity distance in ASD, indicating shorter average connection length and increased short-range connectivity, particularly in transmodal brain systems.

Three Subtypes Of Autism Spectrum Disorder With Transcriptomic Signatures Derived From Morphometric Similarity Networks

The paper identifies three ASD subtypes using morphometric similarity networks and finds distinct transcriptomic and functional connectome patterns associated with each subtype.

Developmental changes in diffusion markers of neurite vary across the hippocampus and covary with the cellular composition of hippocampal tissue

The paper examines developmental changes in hippocampal neurite diffusion markers and their correlation with cell-type composition using MRI and gene-expression data.

High-effect gene-coding variants impact cognition, mental well-being, and neighborhood safety substrates in brain morphology

The paper investigates the impact of rare high-effect genetic variants on brain morphology and related behavioral traits in adolescents using the ABCD cohort.

Predicting depression risk in early adolescence via multimodal brain imaging

The paper predicts depression risk in early adolescents using multimodal brain imaging features and machine learning, finding that resting-state functional connectomes outperform other neuroimaging derivatives.

The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood.

This study characterizes the developmental trajectories of brain metabolites measured by 1H-MRS from childhood to early adulthood, identifying non-linear changes in several metabolites and their associations with cognitive development.

Transcriptomic signatures of Abeta- and tau-induced neuronal dysfunction reveal inflammatory processes at the core of Alzheimer's disease pathophysiology

The paper uses computational models to identify transcriptomic signatures linked to Aβ and tau-induced neuronal dysfunction in Alzheimer's disease, highlighting immune and inflammatory processes.