Enhancing Sox/Oct cooperativity induces higher-grade developmental reset
Caitlin M. MacCarthy, Guangming Wu, Vikas Malik, Yotam Menuchin-Lasowski, Taras Velychko, Gal Keshet, Rui Fan, Ivan Bedzhov, George McDonald Church, Ralf Jauch, Vlad Cojocaru, Hans Robert Schöler, Sergiy Velychko
This study identifies a Sox2 mutation that enhances Sox/Oct cooperativity, improving iPSC reprogramming efficiency and enabling reprogramming of aged cells across species.
Cell stem cell · Dec 22, 2023Peer-reviewedDevelopmental Biology