Author

Ralf Jauch

University of Hong KongORCID 0000-0002-6590-9579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Andrew P. HutchinsiD· 2 shared Gang MaiD· 2 shared Li SuniD· 2 shared Xiuling Fu· 2 shared Bobo Wing-Yee MokiD· 1 shared Boping Deng· 1 shared Caitlin M. MacCarthyiD· 1 shared Carl WardiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Andrew P. HutchinsORCID

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Author profile →

4 papers

Recent·Most cited

High-resolution RNA knockdown profiles of small RNA and Cas13 systems

Jonathan Kong, Summerloretta S. K. Leung, Guojia Wu, Chi Fai Lau, Bobo Wing-Yee Mok, Mingxi Weng, Ralf Jauch, Honglin Chen, S. Chul Kwon

This study compares RNA knockdown profiles of small RNA and Cas13 systems to identify structural rules governing target-site selection.

bioRxiv · Nov 17, 2025 · PreprintMolecular Biology

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

Li Sun, Xiuling Fu, Zhen Xiao, Gang Ma, Yibin Zhou, Haoqing Hu, Liyang Shi, Dongwei Li, Ralf Jauch, Andrew P. Hutchins

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Advanced Science · Dec 10, 2024Peer-reviewedCell Biology

Enhancing Sox/Oct cooperativity induces higher-grade developmental reset

Caitlin M. MacCarthy, Guangming Wu, Vikas Malik, Yotam Menuchin-Lasowski, Taras Velychko, Gal Keshet, Rui Fan, Ivan Bedzhov, George McDonald Church, Ralf Jauch, Vlad Cojocaru, Hans Robert Schöler, Sergiy Velychko

This study identifies a Sox2 mutation that enhances Sox/Oct cooperativity, improving iPSC reprogramming efficiency and enabling reprogramming of aged cells across species.

Cell stem cell · Dec 22, 2023Peer-reviewedDevelopmental Biology

Transposable Element-Gene Splicing Modulates the Transcriptional Landscape of Human Pluripotent Stem Cells

Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, , Andrew P. Hutchins

This study shows that transposable elements contribute to the transcriptome of human pluripotent stem cells by being spliced into coding and non-coding transcripts, affecting gene expression and generating novel peptides.

bioRxiv · Jul 26, 2020 · PreprintGenomics