Author

Norikazu Saiki

Institute of Integrated Research, Institute of Science TokyoORCID 0000-0002-0830-4848Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Kentaro IwasawaiD· 2 shared Takanori TakebeiD· 2 shared Aaron M. ZorniD· 1 shared Alexander J. BondociD· 1 shared Connie Santangelo· 1 shared Eri Kawakami· 1 shared Hasan Al RezaiD· 1 shared Hee-Wong Lim· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersDevelopmental Biology

Kentaro IwasawaORCID

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2 papers

Recent·Most cited

Self-Organization of Sinusoidal Vessels in Pluripotent Stem Cell-derived Human Liver Bud Organoids

Norikazu Saiki, Yasunori Nio, Yosuke Yoneyama, Shuntaro Kawamura, Kentaro Iwasawa, Eri Kawakami, Kohei Araki, Junko Fukumura, Tsuyoshi Sakairi, Tamaki Kono, Rio Ohmura, Masaru Koido, Masaaki Funata, Wendy L. Thompson, Pamela Cruz‐Encarnacion, , Takanori Takebe

This study develops a method to generate human liver bud organoids with functional sinusoidal vessels, demonstrating their potential for coagulation disorder therapies.

Nature Biomedical Engineering · Jun 25, 2025Peer-reviewedDevelopmental Biology

Primitive Hepatoblasts Driving Early Liver Development

Kentaro Iwasawa, Hiroyuki Koike, Hasan Al Reza, Yuka Milton, Keishi Kishimoto, Konrad Thorner, Marissa Granitto, Norikazu Saiki, Connie Santangelo, Kathryn Glaser, Masaki Kimura, Alexander J. Bondoc, Hee-Wong Lim, Mitsuru Morimoto, Makiko Iwafuchi, , Takanori Takebe

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

bioRxiv · Jun 8, 2025 · PreprintDevelopmental Biology